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  • 3.1 Clinical development program Neramexane/tinnitus
    • 3.1.1 Tinnitus
      • 3.1.1.1 Tinnitus basic facts
      • 3.1.1.2 Subjective tinnitus
      • 3.1.1.3 Impact on daily life
      • 3.1.1.4 Treatment options
      • 3.1.1.5 Practical ways to cope
      • 3.1.1.6 Links
    • 3.1.2 Neramexane

Tinnitus Facts

The expression "I hear something you don't" sums up the phenomenon of tinnitus fairly well. The umbrella term for symptoms such as noises or ringing in the ears (assuming these are not caused by external sounds) is tinnitus aurium.

Tinnitus is a very common phenomenon: roughly one in three adults in the Western world has experienced it at some time. Eight percent say tinnitus is generally irritating or disturbs their falling asleep, while 0.5 percent say it severely affects their everyday lives.

Tinnitus is a symptom that can have many different causes and forms. Tinnitus can be classified as follows:

• By severity
  Persons with mild tinnitus hear a sound in their ears, but can deal with it in such a way that no other symptoms occur, and there is little or no distress.
  In more severe cases, sounds in the ears increasingly affect all aspects of life. This leads to additional symptoms such as anxiety, sleeping disorders, loss of concentration or depression - with all the distress these entail. Interestingly, there is hardly any connection between tinnitus volume, and the extent to which it affects patients. One way of classifying tinnitus is by using five grades (low to high) according to THI-12. This questionnaire covers various aspects such as irritation caused by tinnitus, anxiety and frustration, and also the extent to which it impairs social life, work or housework.
• Tinnitus with and without hearing loss
  Many tinnitus patients experience limited hearing ability. Often, frequency of the most pronounced hearing loss is the same as frequency of the tinnitus.
• Acute, subacute and chronic tinnitus
  Tinnitus is described as acute if it is less than three months old. Sub-acute tinnitus persists between 3 and 12 months. Chronic tinnitus is older than 12 months.
• Objective and subjective tinnitus
  Objective, or rather objectifiable, tinnitus is caused by an internal sound source (e.g. blood flow or pulsating tumors) that can be made audible and measured externally. Subjective tinnitus is caused by a malfunction in the inner ear or hearing tract; no sound waves are involved. Subjective tinnitus is much more common than objective tinnitus.

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